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KMID : 0357919850190020168
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Korean Journal of Pathology
1985 Volume.19 No. 2 p.168 ~ p.178
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Clinical Application of EMA, CEA and LCA in Differential Diagnosis of tumors
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Abstract
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To determine the therapeutic plan and to predict the prognosis, it is a pivotal an4
important task to differentiate the exact nature of the various undifferentiated neoplasms.
In order to solve this problem, the electron microscopy has once beta considered only
method in certain cases. Recently, however, the immunoperoxidase staining method
which is less expensive and easier to use than electron microscopy has been developed
and introduced.
To evaluate the diagnostic value of epithelial membrane antigen(EMA),
carcinoembryonic antigen(CEA) and leukocyte common antigen (LCA) immunoperoxidase
method, the authors applied these staining in 15 cases which exact diagnoses were
difficult with conventional routine an4 special stains, using the formalin-fixed and
paraffin-emb-edded tissue sections.
The results are as follows:
1) EMA was helpful in confirming the diagnosis or revising to the proper diagnosis of
undifferentiated carcinoma in 4 of 6 cases and in excluding the possibility of
hepatocellular carcinoma and melanoma in 2 cases, respectively. The negative
stainabilities in one case of choriocarcinoma and one case of malignant fibrous
histiocytoma was useful to exclude the possibility of squamous cell carcinoma and the
positive stainability in one case of giant cell carcinoma to exclude the possibility of
sarcoma.
2) The diagnostic value of CEA was similar to that of EMA; CEA was useful to
differentiate from malignant Iymphoma in one case of epithelial tumor in which CEA
was positive and EMA negative.
3) LCA was useful to differentiate one case of malignant Iymphoma from
undifferentiated carcinoma and to confirm Ewing's sarcoma from malignant Iymphoma in
one case.
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KEYWORD
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